Twice-Fanged Serpent is a medium armor set. When you deal damage, your Physical Penetration is increased by 860 for 3 seconds, stacking up to 5 times.

You can get a total of 4300 Physical Penetration with this set, as long as you can guarantee constant damage on the enemy. The Physical Penetration stacks with all kinds of damage. That means that the set is usually at full stacks in 2 seconds due to all the Damage-over-Time effects that are applied on the enemy. Twice-Fanged Serpent offers the highest Physical Penetration that you can acquire from any set in the game. The set is usually used on Lone Wolf Stamina setups, because they usually lack Physical Penetration from group buffs/debuffs. In Trial groups Physical Penetration is usually provided through other means if the group is well organized, therefore this set is not always needed because the Physical Penetration cap might already be reached.

The Twice-Fanged Serpent set is part of the base game and can be acquired in Sanctum Ophidia, one of the three Craglorn Trials. Each set item of Twice-Fanged Serpent is bound on equip and you can acquire medium armor, jewelry and weapons for the set. It comes in the Celestial motif style.